Sustainability and improving health in buildings are increasingly important aspects, as we spend much of our time indoors. Sustainable architecture and the elimination of toxic compounds in construction are necessary practices to improve indoor air quality. Sick Building Syndrome can be caused by poor ventilation, inadequate temperatures, low humidity, inadequate lighting and noise, and contaminants in indoor air. To improve air quality, measures can be taken such as adequate ventilation, the use of filters, and the incorporation of air purification technologies, such as PUROH’s Open-Air Factor. This technology neutralizes toxic compounds and pathogens in the air and on surfaces, using neutral hydroxyl radicals produced in the troposphere. It is a very affordable and effective technology, without the need for building works.